---
title: "Isa Design Hotel vs Twenty One Hotel: which hotel is better?"
description: "Isa Design Hotel or Twenty One Hotel in Rome? Compare guest ratings, location, amenities, rooms and prices side by side."
url: https://stayversus.com/en/compare/isa-design-hotel-rome-vs-twenty-one-hotel-rome/
language: en
source: StayVersus (https://stayversus.com)
retrieved: 2026-11-09
---

# Isa Design Hotel vs Twenty One Hotel

Both are in Rome, 230 m apart. Here is where each one is stronger.

Hotel · ★★★★ · Prati
## [Isa Design Hotel](https://stayversus.com/en/hotel/isa-design-hotel-rome/)

- **Guest rating:** 8.7 ·  Very good

- **Location score:** 8.1

- **Score by category:** 1 of 5

[Check rates](https://stayversus.com/go/1667830/agoda/?lang=en)

Hotel · ★★★★ · Prati
## [Twenty One Hotel](https://stayversus.com/en/hotel/twenty-one-hotel-rome/)

- **Guest rating:** 8.2 ·  Very good

- **Location score:** 8.1

- **Score by category:** 2 of 5

[Check rates](https://stayversus.com/go/2251612/agoda/?lang=en)

The short answer

## Pick Twenty One Hotel

It leads in 2 of 5 categories. 230 m apart.

### Choose Isa Design Hotel if you want

-   the more consistently praised stay (8.7 / 8.2)
-   a smaller, quieter hotel (Rooms: 50 / 96)
-   a newer or recently renovated building (2016 / 2010)

### Choose Twenty One Hotel if you want

-   a big hotel with more facilities (Rooms: 96 / 50)

### Why is Isa Design Hotel better than Twenty One Hotel?

1.  Higher guest rating (8.7 vs 8.2) (+0.5)
2.  Newer or more recently renovated (2016 vs 2010) (+6y)

### Why is Twenty One Hotel better than Isa Design Hotel?

1.  More guest reviews (293 vs 133), so the rating is more reliable (×2.2)
2.  5 more listed amenities (22 vs 17) (+5)
3.  Has a gym
4.  Has 24-hour room service
5.  Has an on-site restaurant

## All compared facts

Every category is scored from 0 to 10 with the same formula for every hotel.

 

|  | Isa Design Hotel | Twenty One Hotel |
| --- | --- | --- |
| Score by category |
| Guest rating | 8.7  (+0.5) | 8.2 |
| Location | 8.1 | 8.1 |
| Facilities | 5.0 | 8.3  (+3.3) |
| Spa & wellness | 0.0 | 1.5  (+1.5) |
| Public transport | 5.9 | 6.0 |
| Ratings & reviews |
| StayVersus score | 8.6  (+0.4) | 8.2 |
| Guest rating | 8.7  (+0.5) | 8.2 |
| Number of reviews | 133 | 293  (+160) |
| Rank in Rome | top 21%  (+45%) | bottom 34% |
| Location |
| Location score | 8.1 | 8.1 |
| Distance to Prati centre | 330 m | 350 m |
| To public transport | 920 m | 890 m |
| To the airport | 16 km | 16 km |
| Restaurants within 500 m | 150 | 150 |
| To the nearest food shop | 110 m | 160 m |
| Shops within 500 m | 14 | 16 |
| Sights within 1 km | 40 | 40 |
| Rooms & building |
| Star rating | ★★★★ | ★★★★ |
| Rooms | 50 | 96 |
| Floors | 4 | 5 |
| Newest building or renovation | 2016  (+6y) | 2010 |
| Listed amenities | 17 | 22  (+5) |
| Policies |
| Check-in from | 15:00 | 15:00 |
| Check-out until | 11:00 | 11:00 |
| Amenities |
| Free Wi-Fi | ✓ | ✓ |
| Airport transfer | ✓ | ✓ |
| Shuttle | ✓ | ✓ |
| Car hire | ✓ | ✓ |
| Concierge | ✓ | ✓ |
| Laundry | ✓ | ✓ |
| Luggage storage | ✓ | ✓ |
| Breakfast | ✓ | ✓ |
| Bar | ✓ | ✓ |
| Terrace | ✓ | ✓ |
| Air conditioning | ✓ | ✓ |
| Balcony | ✓ | ✓ |
| Minibar | ✓ | ✓ |
| In-room safe | ✓ | ✓ |
| Blackout curtains | ✓ | – |
| Parking | – | ✓ |
| 24-hour front desk | – | ✓ |
| Restaurant | – | ✓ |
| 24-hour room service | – | ✓ |
| Gym | – | ✓ |
| Coffee or tea maker | – | ✓ |
| Distance to the main sights |
| Colosseum | 2.7 km | 2.8 km |
| St. Peter's Basilica | 1.4 km | 1.5 km |
| Roman Forum | 2.1 km | 2.3 km |
| Trevi Fountain | 1.4 km | 1.5 km |
| Archbasilica of St. John Lateran | 3.9 km | 4.0 km |
| Castel Sant'Angelo | 480 m  (−220 m) | 700 m |
| Which hotel suits you |
| Spa & relaxation | – | ✓ |

## Live prices around both hotels

Real nightly rates from booking partners for the dates you picked above. Tap a price for the offer.

## Location

230 m apart

Isa Design Hotel: city centre: 1.2 km, nearest station Ottaviano – San Pietro – Musei Vaticani: 920 m, Ciampino–G. B. Pastine International Airport (CIA): 16 km, 150+ places to eat within 500 m, 40+ sights within 1 km.

Twenty One Hotel: city centre: 1.4 km, nearest station Ottaviano – San Pietro – Musei Vaticani: 890 m, Ciampino–G. B. Pastine International Airport (CIA): 16 km, 150+ places to eat within 500 m, 40+ sights within 1 km.

[Top-rated of 127 hotels in Prati](https://stayversus.com/en/italy/rome/area/prati/)

## Weather in Rome

[Rome weather: 15-day forecast](https://atlasofseasons.com/en/italy/lazio/rome/weather)

## Isa Design Hotel or Twenty One Hotel: common questions

### Which is better, Isa Design Hotel or Twenty One Hotel?

Twenty One Hotel leads in 2 of 5 categories, including facilities, spa & wellness. Isa Design Hotel is stronger in guest rating.

### Which is cheaper, Isa Design Hotel or Twenty One Hotel?

Prices change by date. Pick your dates above to see both nightly prices side by side.

### How far apart are Isa Design Hotel and Twenty One Hotel?

The two hotels are 230 m apart in a straight line.

## Compare now

Updated 6 Oct 2026. Data: Agoda, Overture Maps, OpenStreetMap, OurAirports and hotels' own websites. We may earn a commission from partner links; it never changes the comparison. [How we score](https://stayversus.com/en/about/)

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Source: https://stayversus.com/en/compare/isa-design-hotel-rome-vs-twenty-one-hotel-rome/. Facts are compiled by StayVersus from partner data (Agoda), Overture Maps, OpenStreetMap, OurAirports, public Google Maps listings and hotels' own websites. Scores use one formula for every hotel. Methodology: https://stayversus.com/en/about/