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Hotel Isa vs Twenty One Hotel

Both are in Rome, 250 m apart. Here is where each one is stronger.

Hotel★★★★Prati

Hotel Isa

Guest rating
9.2 Excellent
Location score
8.0
Score by category
1 of 3
Check rates

Hotel★★★★Prati

Twenty One Hotel

Guest rating
8.2 Very good
Location score
8.1
Score by category
0 of 3
Check rates

The short answer

Too close to call

Neither hotel has a clear edge on the facts we have. Your priorities decide. 250 m apart.

Choose Hotel Isa if you want

  • the more consistently praised stay (9.2 / 8.2)
  • breakfast included

Why is Hotel Isa better than Twenty One Hotel?

  1. 1Higher guest rating (9.2 vs 8.2)+1.0
  2. 2Includes free breakfast

Why is Twenty One Hotel better than Hotel Isa?

  1. 1More guest reviews (293 vs 6), so the rating is more reliable×49

All compared facts

Every category is scored from 0 to 10 with the same formula for every hotel.

Hotel Isa vs Twenty One Hotel: which hotel is better?
Hotel Isa vs Twenty One Hotel: which hotel is better?Hotel IsaTwenty One Hotel
Score by category
Guest rating 9.2 +1.0 8.2
Location 8.0 8.1
Facilities – 8.3
Spa & wellness – 1.5
Public transport 5.7 6.0
Ratings & reviews
StayVersus score 8.5 +0.2 8.2
Guest rating 9.2 +1.0 8.2
Number of reviews 6 293 +287
Rank in Rome top 37% +29% bottom 34%
Location
Location score 8.0 8.1
Distance to Prati centre 370 m 350 m
To public transport 950 m 890 m
To the airport 16 km 16 km
Restaurants within 500 m 150 150
To the nearest food shop 110 m 160 m
Shops within 500 m 13 16 +3
Sights within 1 km 40 40
Rooms & building
Star rating ★★★★ ★★★★
Rooms – 96
Floors – 5
Newest building or renovation – 2010
Listed amenities 11 22 +11
Policies
Check-in from 15:00 15:00
Check-out until 11:00 11:00
Amenities
Free Wi-Fi ✓ ✓
Parking ✓ ✓
24-hour front desk ✓ ✓
Free breakfast ✓ –
Bar ✓ ✓
Wheelchair accessible ✓ –
Minibar ✓ ✓
In-room safe ✓ ✓
Airport transfer – ✓
Shuttle – ✓
Car hire – ✓
Concierge – ✓
Laundry – ✓
Luggage storage – ✓
Restaurant – ✓
24-hour room service – ✓
Gym – ✓
Terrace – ✓
Air conditioning – ✓
Balcony – ✓
Coffee or tea maker – ✓
Distance to the main sights
Colosseum 2.6 km 2.8 km
St. Peter's Basilica 1.4 km 1.5 km
Roman Forum 2.1 km 2.3 km
Trevi Fountain 1.3 km 1.5 km
Archbasilica of St. John Lateran 3.8 km 4.0 km
Castel Sant'Angelo 480 m −220 m 700 m
Which hotel suits you
Spa & relaxation – ✓

Price for your dates

Prices come from booking partners and can change. The final price is shown before you book.

Live prices around both hotels

Real nightly rates from booking partners for the dates you picked above. Tap a price for the offer.

Location

250 m apart

Hotel Isa: city centre: 1.2 km, nearest station Ottaviano – San Pietro – Musei Vaticani: 950 m, Ciampino–G. B. Pastine International Airport (CIA): 16 km, 150+ places to eat within 500 m, 40+ sights within 1 km.

Twenty One Hotel: city centre: 1.4 km, nearest station Ottaviano – San Pietro – Musei Vaticani: 890 m, Ciampino–G. B. Pastine International Airport (CIA): 16 km, 150+ places to eat within 500 m, 40+ sights within 1 km.

Top-rated of 127 hotels in Prati

Weather in Rome

Hotel Isa or Twenty One Hotel: common questions

Which is better, Hotel Isa or Twenty One Hotel?

Hotel Isa leads in 1 of 3 categories, including guest rating.

Which is cheaper, Hotel Isa or Twenty One Hotel?

Prices change by date. Pick your dates above to see both nightly prices side by side.

How far apart are Hotel Isa and Twenty One Hotel?

The two hotels are 250 m apart in a straight line.

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Updated 6 Oct 2026. Data: Agoda, Overture Maps, OpenStreetMap, OurAirports and hotels' own websites. We may earn a commission from partner links; it never changes the comparison. How we score